Biography

In my academic studies, I focused on the structure and function of the central nervous system with special emphasis on the role of the limbic system in memory and learning, the neurophysiological mechanisms regulating sleep and the organization of the visual system. In my professional career as a toxicologist, beginning with an Industrial Postdoctoral Fellowship at Bioresearch Laboratories in Montreal, I have conducted the full spectrum of toxicological studies including inhalation, reproductive, developmental, chronic toxicity and carcinogenicity studies. I specialized in evaluating the effects of xenobiotics on the endocrine and nervous systems. My involvement with quantitative risk assessment began by leading an industry team in the creation of a software program to conduct cumulative and aggregated risk assessment (CARES) using stochastic probabilistic risk assessment tools. Recently I have integrated physiological based pharmacokinetics (PBPK) models into such analyses. I have also been involved in the development of approaches for integrating epidemiological data into hazard based weight-of-the-evidence risk assessments.

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Selected Publications

• Adami H-O, Berry SC, Breckenridge CB, Smith LL, Swenberg JA, Trichopoulos D, Weiss NS and Pastoor TP (2011). Toxicology and epidemiology: improving the science with a framework for combining toxicological and epidemiological evidence to establish causal inference. Toxicol Sci122: 223-234.

• Breckenridge CB, Sturgess NC, Butt M, Wolf JC, Zadory D, Beck M, Mathews JM, Tisdel MO, Minnema D, Travis KZ, Cook AR, Botham PA and Smith LL (2013). Pharmacokinetic, neurochemical, stereological and neuropathological studies on the potential effect of paraquat in the substantia nigra pars compacta of male C57Bl/6J mice. Neurotoxicology 37: 1-14.

• Breckenridge CB, Holden, L, Sturgess N, Weiner M, Sheets L, Sargent D, Soderlund DM, Choi JS, Symington S, Clarke JM, Burr S and Ray D (2009). Evidence for a separate mechanism of toxicity for the Type I and the Type II pyrethroid insecticides. Neurotoxicology 30 Suppl 1: S17-S31.

• Breckenridge CB, Berry C, Chang ET, Sielken RL Jr, Mandel JS (2016). Association between Parkinson’s disease and cigarette smoking, rural living, well-water consumption, farming and pesticide use: systematic review and meta-analysis. PLoS One 11(4): e0151841. doi:10.1371/journal.pone.0151841.

• Breckenridge CB, Campbell JL, Clewell HJ, Andersen ME, Valdez-Flores C, and Sielkin RL Jr (2016). PBPK-based risk assessment for total chlorotriazines in drinking water. Toxicol Sci150: 269-282.

• Hovey RC, Coder PS, Wolf JC, Sielken RL Jr, Tisdel MO and Breckenridge CB (2010). Quantitative assessment of mammary gland development in female Long Evans rats following in utero exposure to atrazine. Toxicol Sci 119: 380-390.